Interaction of promethazine with other drugs

The following interactions occur when combining some medications with promethazine: Levodopa, m-cholinomimetics, dopamine, anticholinesterase drugs, ephedrine, guanethidine – their effects are weakened; Sleeping pills, hypotensive drugs, analgesics, local anesthetics, neuroleptics, m-cholinoblockers, tranquilizers, anesthetics – their effects are enhanced; with beta-adrenoblockers there is a mutual increase in blood plasma concentrations; barbiturates decrease activity and accelerate excretion […]

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